Nature

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

  • E.L.B. and V.G.S. conceived the study. E.L.B., S.K.N. and V.G.S. designed the study. S.K.N., X.L., O.I.G., D.E.K. and M.M. performed experiments. E.L.B., X.L., A.G.B., J.K., M.T., A.H., T.K., C.A.L., A.L.d.L.P., D.E.K., B.L. and C.E. performed computational and statistical analyses. C.C. and B.M.N. contributed to genetic analysis of UKBB. A.G.B., C.E., P.N., P.W.F.W., K.C., S.P., J.M.G., C.J.O. and S.K. contributed to genetic analysis of the Million Veteran Program. J.K., A.H., T.K., A.P. and M.J.D. contributed to genetic analysis of FinnGen. M.T., B.L. and A.R. contributed to analysis of the Human Cell Atlas. V.C., C.P.N. and N.J.S. contributed to genetic analysis of leukocyte telomere length. C.J.W. and A.d.l.C. contributed to genetic analysis of AML. A.L.d.L.P., B.N., J.E.D. and M.M. contributed ideas and insights. V.G.S. supervised all experimental and analytic aspects of this work. E.L.B., S.K.N., X.L. and V.G.S. wrote the manuscript with input from all authors. All authors read and approved the final version of the manuscript.

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